Morten Sandvik, Dr. scient.

Section for Chemistry
Norwegian Veterinary Institute
Elizabeth Stephansens vei 1
1433 Ås
Norway

Tel.: +47 477 53 310
E-mail: morten.sandvik@vetinst.no

Cristin
Researchgate

Research interests

Main areas of interest are toxicology, biochemistry and analytical chemistry; method development and analysis of biotoxins, in vitro methods for metabolism of xenobiotics and methodologies used to separate and isolate products from drug metabolism and biotoxins.

Background

Studies in chemistry, toxicology and biochemistry at the University of Oslo. Master’s degree in toxicology. Doctoral studies in toxicology at the Norwegian School of Veterinary Science: ”Biomarkers in fish: Their application in laboratory and field studies”. Leader of the algal toxin research group at the Norwegian Veterinary Institute since 2004. Research scientist at the Norwegian Veterinary Institute since 1993.

Ongoing projects

PIRE: Advancing global strategies and understanding on the origin of ciguatera fish poisoning in tropical oceans (2018-2022)

Recent projects

Articles

  • Samdal IA, Sandvik M, Vu J, Sukenthirarasa MS, Kanesamurthy S, Løvberg KLE, Kilcoyne J, Forsyth CJ, Wright EJ, Miles CO. Preparation and characterization of an immunoaffinity column for the selective extraction of azaspiracids. J Chromatogr B 2022, 1207, 123360.
  • Sandvik M, Miles CO, Løvberg KLE, Kryuchkov F, Wright EJ, Mudge EM, Kilcoyne J, Samdal IA. In vitro metabolism of azaspiracids 1–3 with a hepatopancreatic fraction from blue mussels (Mytilus edulis). J Agric Food Chem 2021, 69, 11322–11335.
  • Eriksen, G. S.; Knutsen, H. K.; Sandvik, M.; Brantsæter, A.-L., Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups. Environment International 2021, 157, 106804.
  • Sandvik, M.; Miles, C.O.; Wilkins, A.L.; Fæste, C. In vitro hepatic biotransformation of the algal toxin pectenotoxin-2. Toxicon: X 2020, 6, 100031.
  • Miles, C. O.; Sandvik, M.; Nonga, H. E.; Rundberget, T.; Wilkins, A. L.; Rise, F.; Ballot, A. Identification of microcystins in a Lake Victoria cyanobacterial bloom using LC-MS with thiol derivatization. Toxicon 2013, 70, 21–31.
  • Miles, C. O.; Sandvik, M.; Haande, S.; Nonga, H. E.; Ballot, A. LC-MS analysis with thiol derivatization to differentiate [Dhb7]- from [Mdha7]-microcystins: analysis of cyanobacterial blooms, Planktothrix cultures and European crayfish from Lake Steinsfjorden, Norway. Environmental Science and Technology 2013, 47, 4080–4087.
  • Ballot, A.; Sandvik, M.; Rundberget, T.; Botha, C. J.; Miles, C. O. Diversity of cyanobacteria and cyanotoxins in Hartbeespoort Dam, South Africa. Marine and Freshwater Research, in press.
  • Nonga, H. E.; Mdegela, R. H.; Lie, E.; Sandvik, M.; Skaare, J. U. Socio-economic values of wetland resources around Lake Manyara, Tanzania: assessment of environmental threats and local community awareness on environmental degradation and their effects. Journal of Wetlands Ecology 2010, 4, 83-101.
  • Mdegela, R. H.; Braathen, M.; Mosha, R. D.; Skaare, J. U.; Sandvik, M. Assessment of pollution in sewage ponds using biomarker responses in wild African sharptooth catfish (Clarias gariepinus) in Tanzania. Ecotoxicology 2010, 19 (4), 722-734.
  • Mdegela, R. H.; Mosha, R. D.; Sandvik, M.; Skaare, J. U. Assessment of acetylcholinesterase activity in Clarias gariepinus as a biomarker of organophosphate and carbamate exposure. Ecotoxicology 2010, 19 (5), 855-863.
  • Braathen, M.; Mortensen, A. S.; Sandvik, M.; Skare, J. U.; Arukwe, A. Estrogenic effects of selected hydroxy polychlorinated biphenyl congeners in primary culture of Atlantic Salmon (Salmo salar) hepatocytes. Archives of Environmental Contamination and Toxicology 2009, 56 (1), 111-122.
  • Braathen, M.; Mdegela, R. H.; Correia, D.; Rundberget, T.; Myburgh, J.; Botha, C.; Skaare, J. U.; Sandvik, M. Vitellogenin in African sharptooth catfish (Clarias gariepinus): purification, characterization, and ELISA development. Journal of Toxicology and Environmental Health, Part A 2009, 72 (3-4), 173-183.
  • Rundberget, T.; Gustad, E.; Samdal, I. A.; Sandvik, M.; Miles, C. O. A convenient and cost-effective method for monitoring marine algal toxins with passive samplers. Toxicon 2009, 53 (5), 543-550.
  • Torgersen, T.; Lindegarth, S.; Ungfors, A.; Sandvik, M. Profiles and levels of fatty acid esters of okadaic acid group toxins and pectenotoxins during toxin depuration. Part I: brown crab (Cancer pagurus). Toxicon 2008, 52 (3), 407-417.
  • Torgersen, T.; Sandvik, M.; Lundve, B.; Lindegarth, S. Profiles and levels of fatty acid esters of okadaic acid group toxins and pectenotoxins during toxin depuration. Part II: blue mussels (Mytilus edulis) and flat oyster (Ostrea edulis). Toxicon 2008, 52 (3), 418-427.
  • Larsen, K.; Petersen, D.; Wilkins, A. L.; Samdal, I. A.; Sandvik, M.; Rundberget, T.; Goldstone, D.; Arcus, V.; Hovgaard, P.; Rise, F.; Rehmann, N.; Hess, P.; Miles, C. O. Clarification of the C-35 stereochemistries of dinophysistoxin-1 and dinophysistoxin-2 and its consequences for binding to protein phosphatase. Chemical Research in Toxicology 2007, 20 (6), 868-875.
    Mortensen, A. S.; Braathen, M.; Sandvik, M.; Arukwe, A. Effects of hydroxy-polychlorinated biphenyl (OH-PCB) congeners on the xenobiotic biotransformation gene expression patterns in primary culture of Atlantic salmon (Salmo salar) hepatocytes. Ecotoxicology and Environmental Safety 2007, 68 (3), 351-360.
  • Rundberget, T.; Sandvik, M.; Larsen, K.; Pizarro, G. M.; Reguera, B.; Castberg, T.; Gustad, E.; Loader, J. I.; Rise, F.; Wilkins, A. L.; Miles, C. O. Extraction of microalgal toxins by large-scale pumping of seawater in Spain and Norway, and isolation of okadaic acid and dinophysistoxin-2. Toxicon 2007, 50(7), 960-970.
  • Forsyth, C. J.; Xu, J.; Nguyen, S. T.; Samdal, I. A.; Briggs, L. R.; Rundberget, T.; Sandvik, M.; Miles, C. O. Antibodies with broad specificity to azaspiracids by use of synthetic haptens. Journal of the American Chemical Society 2006, 128 (47), 15114-15116.
  • Mdegela, R.; Myburgh, J.; Correia, D.; Braathen, M.; Ejobi, F.; Botha, C.; Sandvik, M.; Skaare, J. U. Evaluation of the gill filament-based EROD assay in African sharptooth catfish (Clarias gariepinus) as a monitoring tool for waterborne PAH-type contaminants. Ecotoxicology 2006, 15 (1), 51-59.
  • Mdegela, R. H.; Braathen, M.; Correia, D.; Mosha, R. D.; Skaare, J. U.; Sandvik, M. Influence of 17alpha-ethynylestradiol on CYP1A, GST and biliary FACs responses in male African sharptooth catfish (Clarias gariepinus) exposed to waterborne benzo[a]pyrene. Ecotoxicology 2006, 15 (8), 629-637.
  • Finch, S. C.; Wilkins, A. L.; Hawkes, A. D.; Jensen, D. J.; MacKenzie, A. L.; Beuzenberg, V.; Quilliam, M. A.; Olseng, C. D.; Samdal, I. A.; Aasen, J.; Selwood, A. I.; Cooney, J. M.; Sandvik, M.; Miles, C. O. Isolation and identification of (44-R,S)-44,55-dihydroxyyessotoxin from Protoceratium reticulatum, and its occurrence in extracts of shellfish from New Zealand, Norway and Canada. Toxicon 2005, 46 (2), 160-170.
  • Flåøyen, A.; di Menna, M. E.; Wilkins, A. L.; Sandvik, M.; Berndt, S. Summer variation in the concentration of steroidal sapogenins in and the degree of fungal infection on Narthecium ossifragum plants from More og Romsdal County, Norway. Veterinary Research Communications 2004, 28 (3), 225-234.
  • Miles, C. O.; Wilkins, A. L.; Munday, R.; Dines, M. H.; Hawkes, A. D.; Briggs, L. R.; Sandvik, M.; Jensen, D. J.; Cooney, J. M.; Holland, P. T.; Quilliam, M. A.; MacKenzie, A. L.; Beuzenberg, V.; Towers, N. R. Isolation of pectenotoxin-2 from Dinophysis acuta and its conversion to pectenotoxin-2 seco acid, and preliminary assessment of their acute toxicities. Toxicon 2004, 43 (1), 1-9.
  • Miles, C. O.; Wilkins, A. L.; Samdal, I. A.; Sandvik, M.; Petersen, D.; Quilliam, M. A.; Naustvoll, L. J.; Rundberget, T.; Torgersen, T.; Hovgaard, P.; Jensen, D. J. A novel pectenotoxin, PTX-12, in Dinophysis spp. and shellfish from Norway. Chemical Research in Toxicology 2004, 17 (11), 1423-1433.
  • Flåøyen, A.; Wilkins, A. L.; Sandvik, M. Ruminal metabolism in sheep of saponins from Yucca schidigera. Veterinary Research Communications 2002, 26 (2), 159-169.
    Ruus, A.; Sandvik, M.; Ugland, K. I.; Skaare, J. U. Factors influencing activities of biotransformation enzymes, concentrations and compositional patterns of organochlorine contaminants in members of a. marine food web. Aquatic Toxicology 2002, 61 (1-2), 73-87.
  • Egaas, E.; Sandvik, M.; Fjeld, E.; Kallqvist, T.; Goksoyr, A.; Svensen, A. Some effects of the fungicide propiconazole on cytochrome P450 and glutathione S-transferase in brown trout (Salmo trutta). Comparative Biochemistry and Physiology Part C. Pharmacology, Toxicology and Endocrinology 1999, 122 (3), 337-344.
  • Sandvik, M.; Horsberg, T. E.; Skare, J. U.; Kristianingebrigtsen Comparison of dietary and waterborne-exposure with benzo(a)pyrene in rainbow trout (Oncorhynchus mykiss): CYP1A1 induction and tissue disposition. Marine Environmental Research 1998, 46 (1-5), 535-536.
  • Beyer, J.; Sandvik, M.; Skare, J. U.; Egaas, E.; Hylland, K.; Waagbo, R.; Goksoyr, A. Time- and dose-dependent biomarker responses in flounder (Platichthys flesus L) exposed to benzo[a]pyrene, 2,3,3′,4,4′,5-hexachlorobiphenyl (PCB-156) and cadmium. Biomarkers 1997, 2 (1), 35-44.
  • Sandvik, M.; Beyer, J.; Goksoyr, A.; Hylland, K.; Egaas, E.; Skaare, J. U. Interaction of benzo[a]pyrene, 2,3,3′,4,4′,5-hexachlorobiphenyl (PCB-156) and cadmium on biomarker responses in flounder (Platichthys flesus L). Biomarkers 1997, 2 (3), 153-160.
  • Beyer, J.; Sandvik, M.; Hylland, K.; Fjeld, E.; Egaas, E.; Aas, E.; Skare, J. U.; Goksoyr, A. Contaminant accumulation and biomarker responses in flounder (Platichthys flesus L.) and Atlantic cod (Gadus morhua L.) exposed by caging to polluted sediments in Sorfjorden, Norway. Aquatic Toxicology 1996, 36 (1-2), 75-98.
  • Goksoyr, A.; Beyer, J.; Egaas, E.; Grosvik, B. E.; Hylland, K.; Sandvik, M.; Skaare, J. U. Biomarker responses in flounder (Platichthys flesus) and their use in pollution monitoring. Marine Pollution Bulletin 1996, 33 (1-6), 36-45.
  • Hylland, K.; Sandvik, M.; Skare, J. U.; Beyer, J.; Egaas, E.; Goksoyr, A. Biomarkers in flounder (Platichthys flesus): an evaluation of their use in pollution monitoring. Marine Environmental Research 1996, 42 (1-4), 223-227.
  • Beyer, J.; Sandvik, M.; Skare, J. U.; Hylland, K.; Klungsoyr, J.; Husoy, A. M.; Grosvik, B. E.; Maaseide, N. P.; Olsen, S. O.; Gadagbui, B. K. M.; Aas, E.; Goksoyr, A. Biomarker responses in marine fish exposed by caging to contaminated fjord sediments. Marine Environmental Research 1995, 39 (1-4), 344-788.
  • Egaas, E.; Sandvik, M.; Svendsen, N. O.; Skaare, J. U. The separation and identification of glutathione S-transferase subunits from Orthosia gothica. Insect Biochemistry and Molecular Biology 1995, 25 (7), 783-788.
  • Egaas, E.; Skaare, J. U.; Svendsen, N. O.; Sandvik, M.; Falls, J. G.; Dauterman, W. C.; Collier, T. K.; Netland, J. A comparative study of effects of atrazine on xenobiotic metabolizing enzymes in fish and insect, and of the in vitro phase II atrazine metabolism in some fish, insects, mammals and one plant species. Comparative Biochemistry and Physiology Part C. Pharmacology, Toxicology and Endocrinology 1993, 106 (1), 141-149.