Background
Farmed salmon can suffer from virus-caused diseases such as Cardiomyopathy syndrome (CMS) caused by infection with Piscine myocarditis virus (PMCV), and salmon gill poxvirus disease (SGPVD) caused by infection with salmon gill poxvirus (SGPV). Both diseases can lead to serious losses in aquaculture and have a strong impact on fish welfare and economical gains. The early diagnosis of the developing infections would allow a timely onset of mitigating measures. In this context, the discovery of disease-specific biomarkers is of importance because they would be suitable for monitoring the health condition of the fish.
Omics-based methodologies and biomedical chemistry are possible tools for the identification of suitable, measurable biomarkers. Combining several approaches such as proteomics and metabolomics in a multi-omics approach increases the potential of finding relevant biomarkers.
Aims
In CARDIO POX, plasma from already performed virus exposure studies in salmon is used for omics-based analyses with the aim of finding signature proteins and metabolites for CMS and SGPVD. The study materials are already well-characterised with regard to virus load, pathology and mortality. Samples collected at different stages of the disease development will be analysed and changes in protein and metabolite profiles determined and set in relationship to one another by applying different biostatistical applications.
2023 – 2024; funded by the Norwegian Veterinary Institute