Fedor Kryuchkov, PhD

Section for Chemistry
Norwegian Veterinary Institute
Elizabeth Stephansens vei 1
1433 Ås
Norway

Tel.: +47 90276876
E-mail: fedor.kryuchkov@vetinst.no

Cristin
Researchgate

Research interests

My research interests lie in the fields of biochemistry and bioanalysis. In my work I use different MS instrumentation to study small molecules (toxins, xenobiotics, lipids and other metabolites) in living organisms and fluids. Currently, I am involved in the PIRE project and where I am studying biosynthesis and biotransformation of ciguatera toxin family.

Background

I have a degree in synthetic chemistry from SPbGU in Russia (2003) and I got my PhD in mass-spectrometry based proteomics in 2013 at SDU in Denmark. In 2008-2009, I worked as a researcher in NILU in Tromsø, and from 20014-2018 I had positions as a post doc and as a senior engineer at the University of Bergen. In 2018, I started working at NVI in the PIRE-project.

Ongoing projects

CiguaPIRE: Advancing global strategies and understanding on the origin of ciguatera fish poisoning in tropical oceans (2018-2022)

Articles

  • Gwinn JK, Robertson A, Ivanova L, Fæste CK, Kryuchkov F, Uhlig S. Identification and cross-species comparison of in vitro phase I brevetoxin (BTX-2) metabolites in northern Gulf of Mexico fish and human liver microsomes by UHPLC-HRMS(/MS). Toxicon X, 2023, 19, 100168.
  • Windahl, U., Tevell Åberg, A., Kryuchkov, F., Lundgren, S., Tegner, C., Dreimanis, K., Koivisto, S., Simola, O., Sandvik, M., Bernhoft, A. Alpha-chloralose poisoning in cats in three Nordic countries – the importance of secondary poisoning. BMC Veterinary Research 2022, 18, 334.
  • Sandvik M, Miles CO, Løvberg KLE, Kryuchkov F, Wright EJ, Mudge EM, Kilcoyne J, Samdal IA. In vitro metabolism of azaspiracids 1–3 with a hepatopancreatic fraction from blue mussels (Mytilus edulis). Journal of Agricultural and Food Chemistry 2021, 69, 11322–11335.
  • Gwinn, J. K.; Uhlig, S.; Ivanova, L.; Fæste, C. K.; Kryuchkov, F.; Robertson, A., In vitro glucuronidation of Caribbean ciguatoxins in fish: first report of conjugative ciguatoxin metabolites. Chemical Research in Toxicology 2021, 34 (8), 1910-1925.
  • Varland, S., Aksnes, H., Kryuchkov, F., Impens, F., Van Haver, D., Jonckheere, V., Ziegler, M., Gevaert, K., Van Damme, P., Arnesen, T. N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae. Molecular and Cellular Proteomics 2018, 17(12), 2309–2323.
  • Kryuchkov F., Verano-Braga T., and Kjeldsen F. N-terminal Sequence Tagging Using Reliably Determined b2 Ions: A Useful Approach to Deconvolute Tandem Mass Spectra of Co-Fragmented Peptides in Proteomics. Journal of Proteomics 2014, 103, 254–260.
  • Kryuchkov F., Verano-Braga T., Hansen T., Sprenger R. and Kjeldsen F. Deconvolution of Mixture Spectra and Increased Throughput of Peptide Identification by Utilization of Intensified Complementary Ions Formed in Tandem Mass Spectrometry. Journal of Proteome Research 2013, 12(7), 3362–3371.
  • Svane S., Kryuchkov F., Lennartson A., McKenzie C. J., Kjeldsen F. Overcoming the Instability of Gaseous Peptide Phosphate Ester Groups by Dimetal Protection. Angewandte Chemie 2012, 13, 3270–3273.
  • Hansen T. A., Kryuchkov F. and Kjeldsen F. Reduction in Database Search Space by Utilization of Amino Acid Composition Information from Electron Transfer Dissociation and Higher-Energy Collisional Dissociation Mass Spectra, Analytical Chemistry 2012, 84(15), 6638–6645.
  • Kryuchkov F. and Nikiforov V. Enantiomer-specific analysis of Polichloropinene congeners. Journal of Ecological Chemistry, 2010, 19(1), 24-30.
  • Trukhin A., Kruchkov F., Hansen L., Kallenborn R., Kiprianova A. and Nikiforov V. Toxaphene chemistry: separation and characterization of selected enantiomers of the Polychloropinene mixtures. Chemosphere 2007, 67, 1695–1700.
  • Kolehmainen E., Kryuchkov F., Nikiforov V. and Valkonen A. 2,2,5,5,6-exo,8,8,9,10,10- Decachlorobornane. Acta Crystallographica 2007, 63, 327–328.
  • Paasivirta J., Sinkkonen S., Nikiforov V., Kryuchkov F., Kolehmainen E., Laihia K., Valkonen A. And Lahtinen M. 2009. Long-range atmospheric transport of three Toxaphene congeners across Europe. Modeling by chained single-box FATEMOD program. Environmental Science and Pollution Research International 2009, 16(2), 191–205.
  • Vasin V., Kostryukov S., Vovod S., Petrov P., Kryuchkov F., Razin V. Stereodirective synthesis of substituted bicyclo[3.1.1]heptanes. Stereoselective synthesis of substituted bicyclo[3.1.1]heptanes: II. Synthesis of all diastereoisomers of 7-methyl-and 7-phenylbicyclo[3.1.1]hept-6-yl phenyl sulfones from tricyclo[4.1.0.0(2,7)]heptane precursors. Russian Journal of Organic Chemistry 2008, 44(3), 325–330.