Gunnar Sundstøl Eriksen, Dr. scient.

Toxinology Research Group
Norwegian Veterinary Institute
Elizabeth Stephansens vei 1
1433 Ås
NorwayTel.: +47/938 08 479
E-mail: gunnar.eriksen@vetinst.noCristin
Researchgate

Research interests

Toxicological effects of fungal metabolites in feed and food, and the significance of these metabolites on human and animal health.

Background

Master of Science (Cand. Scient.) in Biology/Toxicology at the University of Oslo (“Cytochrome P450 as a marker of environmental pollution”). PhD in animal sciences/toxicology at the Swedish University of Agricultural Sciences in Uppsala Sweden (“Metabolism and toxicity of trichothecenes”). Professional career: Norwegian Food Control Authority 1992-1999, Norwegian Poison Information Centre, 2003-2004. Norwegian Food Safety Authority, 2004, Norwegian Veterinary Institute, 2005 – present. Member of  the Norwegian Scientific Committee for Food and Environment (VKM).

Ongoing projects

ShellFeed – Risk assessment of algal toxins in new marine feed sources for salmon
PARC – European partnership for the assessment of risks from chemicals

NAMC – North Atlantic Microplastic Centre

MycoSafeBread – Innovative cereal processing methods to produce mycotoxin-safe bread (2020-2023).

Recent projects

FUNtox – Fungi and mycotoxins in a «One Health» perspective

MycoProcess – Mycotoxins in cereal based food products of wheat and oats – effect of processing on free/masked mycotoxins and human risk assessment (2014-2017).

Articles

  • Snapkow, I., Smith, N., Arnesdotter, E., Beekmann, K., Blanc, E. B., Braeuning, A., Corsini, E., Dolenc, M.S., Duivenvoorde, L.P.M., Eriksen, G.S., Franko, N., Galbiati, V., Gostner, J.M., Grova, N., Gutleb, A.C., Hargitai, R., Janssen, A.W.F., Krapf, S.A, Lindeman, B., Lumniczky, K., Maddalon, A., Mollerup, S., Parráková, L., Pierzchalski, A., Pieters, R.H.H., Silva, M.J., Solhaug, A., Staal, Y.C.M., Straumfors, A., Szatmári, T., Turner, J.D., Vandebriel, R.J., Zenclussen, A.C., Barouki, R. New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals—a PARC (Partnership for the Assessment of Risk from Chemicals) project. Frontiers in Toxicology 2024, 6, 1339104.
  • Louro H, Vettorazzi A, López de Cerain A, Spyropoulou A, Solhaug A, Straumfors A, Behr A-C, Mertens B, Žegura B, Fæste CK, Ndiaye D, Spilioti E, Varga E, Dubreil E, Borsos E, Crudo F, Eriksen GS, Snapkow I, Henri J, Sanders J, Machera K, Gaté L, Le Hegarat L, Novak M, Smith NM, Krapf S, Hager S, Fessard V, Kohl Y, Silva MJ, Dirven H, Dietrich J, Marko D. Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health. Archives of Toxicology 2024, 98, 425-469.
  • Solhaug, S.; Gjessing, M.; Sandvik, M.; Eriksen, G.S. The gill epithelial cell lines RTgill-W1, from Rainbow trout and ASG-10, from Atlantic salmon, exert different toxicity profiles towards rotenone. Cytotechnology, 2022.
  • Eriksen, G. S.; Knutsen, H. K.; Sandvik, M.; Brantsæter, A.-L., Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups. Environment International 2021, 157, 106804.
  • Hole, A. S.; Rud, I.; Sahlstrøm, S.; Ivanova, L.; Eriksen, G. S.; Divon, H. H., Heat-induced reduction of deoxynivalenol and its modified forms during flaking and cooking of oat. World Mycotoxin Journal 2021, 0 (0), 1-12.
  • Nones, J.; Solhaug, A.; Riella, H. G.; Eriksen, G. S.; Nones, J., Brazilian bentonite and a new modified bentonite material, BAC302, reduce zearalenone-induced cell death. World Mycotoxin Journal 2021, 14 (3), 347-356.
  • van den Brand, A. D.; Hoogenveen, R.; Mengelers, M. J. B.; Zeilmaker, M.; Eriksen, G. S.; Uhlig, S.; Brantsæter, A. L.; Dirven, H. A. A. M.; Husøy, T., Modelling the renal excretion of the mycotoxin deoxynivalenol in humans in an everyday situation. Toxins 2021, 13 (10), 675.
  • Mallia, V.; Ivanova, L.; Ballot, A.; Eriksen,; Harper, E.; Connolly, L.; Uhlig, S.  Investigation of in vitro endocrine activities of Microcystis and Planktothrix cyanobacterial strains. Toxins 2020, 12, 228.
  • Solhaug, A.; Torgersen, M.L.; Holme, J.A.; Wiik-Nilsen, J.; Thiede, B.; Eriksen, G.S. The Fusarium mycotoxin, 2-Amino-14,16-dimethyloctadecan-3-ol (AOD) induces vacuolization in HepG2 cells. Toxicology 2020, 433-434, 152405.
  • Uhlig, S.; Eriksen, G.S.; Hofgaard, I.S.; Krska, R.; Beltran, E.; Sulyok, M. Faces of a changing climate: Semi-quantitative multi-mycotoxin analysis of grain grown in exceptional climatic conditions in Norway. Toxins 2013, 5, 1682-1697. open access
  • Ravnum, S.; Zimmer, K. E.; Keune, H.; Gutleb, A. C.; Murk, A. J.; Koppe, J. G.; Magnanti, B.; Lyche, J. L.; Eriksen, G. S.; Ropstad, E.; Skaare, J. U.; Kobernus, M.; Yang, A.; Bartonova, A.; Krayer von Krauss, M. Policy relevant results from an expert elicitation on the human health risks of decabromodiphenyl ether (decaBDE) and hexabromocyclododecane (HBCD). Environmental Health 2012, 11(Suppl 1), S7.
  • Zimmer, K.; Gutleb, A.; Ravnum, S.; Krayer von Krauss, M.; Murk, A. J.; Ropstad, E.; Skaare, J. U.; Eriksen, G. S.; Lyche, J. L.; Koppe, J. G.; Magnanti, B. L.; Yang, A.; Bartonova, A.; Keune H. Policy relevant results from an expert elicitation on the health risks of phthalates. Environmental Health 2012, 11(Suppl 1), S6.
  • Keune, H.; Gutleb, A. C.; Zimmer, K. E.; Ravnum, S.; Yang, A.; Bartonova, A.; Krayer von Krauss, M.; Ropstad, E.; Eriksen, G. S.; Saunders, M.; Magnanti, B.; Forsberg, B. We’re only in it for the knowledge? A problem solving turn in environment and health expert elicitation. Environmental Health 2012, 11(Suppl 1), S3.
  • Solhaug, A.; Holme, J. A.; Vines, L. L.; Spilsberg, B.; Pestka, J.J.; Haglund, K.; Dendele, B.; Lagadic-Gossmann, D.; Eriksen, G. S. Alternariol-induced ROS causes DNA damage and accumulation in the G2/M transition. Toxicology Letters 2012, 211, 119-119.
  • Eriksen, G. S.; Rundberget, T.; Wigestrand, M. B.; Fonnum, F.; Bernhoft, A.; Moldes-Anaya, A. Poisoning by Penicillium toxins-Clinical and brain receptor effects. Toxicology Letters 2012, 211, 58-59.
  • Ndossi, D. G.; Frizzell, C.; Tremoen, N. H.; Fæste, C. K.; Verhaegen, S.; Dahl, E.; Eriksen, G. S.; Sørlie, M.; Connolly, L.; Ropstad, E. An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins. Toxicology Letters (in press).
  • Holme, J. A.; Gammelsrud, A.; Dendele, B.; Sandberg, W.; Lagadic-Gossmann, D.; Refsnes, M.; Becher, R.; Eriksen, G. S.; Solhaug, A. Mycotoxin-induced cell death and inflammatory responses in macrophages. Toxicology Letters 2012, 211, 133-134.
  • Gammelsrud, A.; Solhaug, A.; Dendele, B.; Sandberg, W. J.; Ivanova, L.; Kobach Bølling, A.; Lagadic-Gossmann, D.; Refsnes, M.; Becher, R.; Eriksen, G. S.; Holme, J. A. Enniatin B-induced cell death and inflammatory responses in RAW 264.7 murine macrophages. Toxicology and Applied Pharmacology 2012, 261, 74-87.
  • Ivanova, L., Uhlig, S., Eriksen, GS., Johannessen, L.E. Enniatin B1 is a substrate of intestinal P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein. 2010. World Mycotoxin Journal 3 (3), 271-281.
  • Eriksen, GS,, Hultin Jäderlund, K., Moldes-Anaya, A., Schönheit, J., Bernhoft, A., Jæger, G., Rundberget, T. Poisoning of dogs with tremorgenic Penicillium toxins. 2010. Medical Mycology 48 (1), 188-196.
    Lyche, JL., Gutleb, AC., Bergman,Å., Eriksen, GS., Murk, AJ., Ropstad, E., Saunders, M., Skaare, JU. 2009. Reproductive and developmental toxicity of phthalates. Journal of Toxicology and Environmental Health 12. 225-249.
  • Moldes-Anaya, AS., Asp, TN., Eriksen, GS., Skaar, I and Rundberget, T. 2009. Determination of cyclopiazonic acid in food and feeds by liquid chromatography–tandem mass spectrometry. Journal of Chromatography A 3812-3818.
  • Gutleb, AC., Bergman, Å., Bjørling-Paulsen, M., Eriksen, GS., Grandjean, P., Jensen, TK., Lyche, JL., Murk, AJ., Ropstad, E., and Skaare, JU. 2008. HENVINET—Health and environment network . Toxicology Letters 180, S1,S30
  • Uhlig, S., Ivanova, L., Bernhoft, A and Eriksen, GS. 2008. 2-amino-14,16-dimethyloctadecan-3-ol: in vitro bioactivity and bio-production by the fungus Fusarium avenaceum. World Mycotoxin Journal 1, 49-58
  • Ivanova, L., Skjerve, E., Eriksen, G.S. and Uhlig, S. (2006), Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum, Toxicon, 47, 868-876.
  • Eriksen, G.S. and Pettersson, H. 2004. Toxicological evaluation of trichothecenes in animal feed. Animal Feed Science and Technology 114 (1-4), 205-239.
  • Eriksen, G.S., Pettersson, H. and Lundh, T. 2004. Comparative cytotoxicity of deoxynivalenol, nivalenol,, their acetylated derivatives and de-epoxy metabolites. Food and Chemical Toxicology.42 (4), 619-624.
  • Eriksen, G.S., Pettersson, H. and Lindberg, J.E. 2003. Absorption, metabolism and excretion of 3-acetyl DON in pigs. Archives of Animal Nutrition. 57. 335-345.
  • Eriksen, G.S. and Pettersson, H. 2003. Lack of de-epoxidation of type B trichothecenes in incubates with human faeces. Food Additives and Contaminants 20(6); 579-582.
  • Eriksen, G.S., Pettersson, H., Johnsen, K. and Lindberg, J.E. 2002. Transformation of trichothecenes in ileal digesta and faeces from pigs. Archives of Animal Nutrition. 56, 263-274.
  • Darnerud, P.O., Eriksen, G.S., Johannesson, T., Larsen, P.B. and Viluksela, M., 2001. Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environmental Health Perspectives 109 Suppl 1, 49-68.

Other scientific reports and monographs

  • Eriksen, GS., Amundsen, CE., Bernhoft, A., Eggen, T., Grave, K., Halling-Sørensen, B., Källqvist, T., Sogn, T., Sverdrup, L. , Risk assessment of the use of sewage sludge as fertilizer. 2009. Norwegian Scientific Committee for Food.
  • Eriken, GS., Bogen Hetland, R., Lyche, JL., Vikse, R. 2006. Risk Assessment of White Phosphorus. Available at: http://www.vkm.no.
    Grotmol T, Bernhoft A, Eriksen GS, Flaten TP. (eds.) 2006. Endocrine disrupters. Proceedings of an international symposium held at the Norwegian Academy of Science and Letters, Oslo, 13-14 October 2005. The Norwegian Academy of Science and Letters, 164 pp. ISBN 978-82-7099-437-3.
  • Eriksen, G. 2006. Effects of phyto- and myco-estrogens in domestic animals. In: Grotmol T, Bernhoft A, Eriksen GS, Flaten TP. (eds.) 2006. Endocrine disrupters. Proceedings of an international symposium held at the Norwegian Academy of Science and Letters, Oslo, 13-14 October 2005. The Norwegian Academy of Science and Letters, 164 pp. ISBN 978-82-7099-437-3.
  • Eriksen, Pennington, and Schlatter, 2000. JECFA. Zearalenone. Joint FAO/WHO Expert Committee on Food Additives, 53rd Report. Safety evaluation of certain food additives and contaminants. WHO Food Additives series (Geneva) 44, 393-482.
  • Eriksen and Alexander (eds.) (1998). Fusarium toxins in cereals-a risk assessment. TemaNord 1998: 502. Nordic Council of Ministers. Copenhagen.
  • Eriksen GS. Metabolism and Toxicity of Trichothecenes: Studies in pigs and a risk assessment of trichothecenes in feed for farm animals. VDM Verlag Saarbrücken, Germany, 2009.