Lada Ivanova, Dr. philos.

Section for Chemistry
Norwegian Veterinary Institute
Ullevålsveien 68
0454 Oslo/Norway

Tel.: +47 915 18 427
E-mail: lada.ivanova@vetinst.no

Cristin
Researchgate

Research interests

Isolation, purification and identification of secondary metabolites from fungi and plants. Mechanistic studies of natural toxins in bioassays.

Background

Master’s degree in analytical chemistry from the University of Kiev, Ukraine. Master’s degree in food safety and Dr. philos. in chemistry and toxicokinetics from the Norwegian School of Veterinary Science Oslo/Norway. Professional experience from numerous projects and studies in the field of mycotoxin analysis. Identification, isolation and structural characterisation of unknown bioactive compounds (LC/MS, preparative HPLC, MSn fragmentation and high-resolution mass spectrometry) and implementation of in vitro methods for evaluating toxicity, absorption and biotransformation of toxic substances are main subjects of expertise. Member of the working group for biotoxins (WG5) under The Technical Committee 275, “Food analysis-Horizontal methods”, within the CEN system (2005-2010). Scientist at the Norwegian Veterinary Institute since 2006.

Ongoing projects

PIRE – Advancing global strategies and understanding on the origin of ciguatera fish poisoning in tropical oceans (2018-2022)

Bio-DIRECT – Biomarkers and Bioassays for Animal and Fish Research and Diagnostics (SIS 2019-2022).

FunTox – Fungi and mycotoxins in a «One Health» perspective (SIS 2013-2018)

iSABreed – ISA resistance in Atlantic salmon: Defining new phenotypes for accurate breeding (2017-2020)

SAFEFISH – Implications of green Fish feed for consumer safety – carry-over of plant peptides, natural toxins and bioactive componds (NFR Havbruk2 – 2016-2020)

PromoFish – Proteomics and metabolomics as tools in aquaculture research: epidermal mucus and the Gyrodactylus salaris mystery

Articles

  • Faeste CK, Pierre F, Ivanova L, Sayyari A, Massotte D. Behavioural and metabolomic changes from chronic dietary exposure to low-level deoxynivalenol reveal impact on mouse well-being. Arch Toxicol 2019, 93, 2087.
  • Oliveira CAF, Ivanova L, Solhaug A, Fæste CK. Effects of enniatin B1 on lysosomal stability and chaperone-mediated autophagy-related components in mouse embryonic fibroblasts. Mycotox Res 2019.
  • Ivanova L, Denisov IG, Grinkova YV, Sligar SG, Faeste CK. Biotransformation of the mycotoxin enniatin B1 by CYP P450 3A4 and potential for drug-drug interactions. Metabolites 2019, 9.
  • Johny A, Faeste CK, Bogevik AS, Berge GM, Fernandes JMO, Ivanova L. Development and validation of a liquid chromatography high-resolution mass spectrometry method for the simultaneous determination of mycotoxins and phytoestrogens in plant-based fish feed and exposed fish. Toxins 2019, 11.
  • Ivanova, L.; Tartor, H.; Grove, S.; Kristoffersen, A.B.; Uhlig, S. Workflow for the targeted and untargeted detection of small metabolites in fish skin mucus. Fishes 2018, 3 (2), 21–34.
  • Ivanova, L.; Fæste, C.K.; Solhaug, A. Role of P-glycoprotein in deoxynivalenol-mediated in vitro toxicity. Toxicology Letters 2018, 284, 21−28.
  • Ivanova, L.; Uhlig, S.; Devreese, M.; Croubels, S.; Fæste, C.K. Biotransformation of the mycotoxin enniatin B1 in pigs: a comparative in vitro and in vivo approach, Food and Chemical Toxicology 2017, 105, 506–517.
  • Ivanova, L.; Sahlstrøm, S.; Rud, I.; Uhlig, S.; Fæste, C.K.; Eriksen, G.S.; Divon, H. Effect of primary processing on the distribution of free and modified Fusarium mycotoxins in naturally contaminated oats, World Mycotoxin Journal 2017, 10, 73–88.
  • Bernhoft, A.; Høgåsen, H.R.; Rosenlund, G.; Ivanova, L.; Berntssen, M.H.G.; Alexander, J.; Eriksen, G.S.; Fæste, C.K. Tissue distribution and elimination of deoxynivalenol and ochratoxin A in dietary exposed Atlantic salmon (Salmo salar). Food additives & contaminants: Part A 2017, 34 (7), 1211−1224.
  • Uhlig, S.; Ivanova, L.; and Fæaste, C. K. Correction to Enzyme-assisted synthesis and structural characterization of the 3-, 8- and 15-glucuronides of deoxynivalenol, Journal of Agricultural and Food Chemistry 2016, 64, 3732.
  • Ivanova, L.; Fæste, C.K.; Delezie, E.; Van Pamel, E.; Daeseleire, E.; Callebaut, A.; Uhlig, S. Presence of enniatin B and its hepatic metabolites in plasma and liver samples from broilers and eggs from laying hens. World Mycotoxin Journal 2014, 7, 167–175.
  • Uhlig, S.; Ivanova, L.; Fæste, C.K. Enzyme-assisted synthesis and structural characterization of the 3‑, 8‑, and 15-glucuronides of deoxynivalenol. Journal of Agricultural and Food Chemistry 2013, 61, 2006-2012.
  • Ivanova, L.; Egge-Jacobsen, W.M.; Solhaug, A.; Thoen, E.; Fæste, C.K. Lysosomes as a possible target of Enniatin B-induced toxicity in Caco-2 cells. Chemical Research in Toxicology 2012, 25, 1662−1674.
  • Gammelsrud, A.; Solhaug, A.; Dendele, B.; Sandberg, W. J.; Ivanova, L.; Kobach Bølling, A.; Lagadic-Gossmann, D.; Refsnes, M.; Becher, R.; Eriksen, G. S.; Holme, J. A. Enniatin B-induced cell death and inflammatory responses in RAW 264.7 murine macrophages. Toxicology and Applied Pharmacology 2012, 261, 74−87.
  • Fæste, C.K.; Ivanova, L.; Uhlig, S. In vitro metabolism of the mycotoxin enniatin B in different species and CYP P450 reaction phenotyping. Drug Metabolism and Disposition 2011, 39, 1768-1776.
  • Ivanova, L.; Fæste, C. K.; Uhlig, S. In vitro metabolism of the depsipeptide enniatin B. Analytical and Bioanalytical Chemistry 2011, 400, 2889-2901.
  • Ivanova, L.; Uhlig, S.; Eriksen, G. S.; Johannessen, L. E. Enniatin B1 is a substrate of intestinal P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein. World Mycotoxin Journal 2010, 3 (3), 271-281.
  • Ivanova, L.; Petersen, D.; Uhlig, S. Phomenins and fatty acids from Alternaria infectoria. Toxicon 2010, 55 (6), 1107-1114.
    Uhlig, S.; Ivanova, L.; Petersen, D.; Kristensen, R. Structural studies on minor enniatins from Fusarium sp VI 03441: Novel N-methyl-threonine containing enniatins. Toxicon 2009, 53 (7-8), 734-742.
  • Ivanova, L.; Uhlig, S. A bioassay for the simultaneous measurement of metabolic activity, membrane integrity, and lysosomal activity in cell cultures. Analytical Biochemistry 2008, 379 (1), 16-19.
  • Uhlig, S.; Ivanova, L.; Bernhoft, A.; Eriksen, G. S. 2-Amino-14,16-dimethyloctadecan-3-ol: in vitro bioactivity and bio-production by the fungus Fusarium avenaceum. World Mycotoxin Journal 2008, 1 (1), 49-58.
  • Uhlig, S.; Vikoren, T.; Ivanova, L.; Handeland, K. Ergot alkaloids in Norwegian wild grasses: a mass spectrometric approach. Rapid Commun. Mass Spectrom. 2007, 21 (10), 1651-1660.
  • Ivanova, L.; Skjerve, E.; Eriksen, G. S.; Uhlig, S. Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum. Toxicon 2006, 47 (8), 868-876.
  • Uhlig, S.; Ivanova, L. Determination of beauvericin and four other enniatins in grain by liquid chromatography-mass spectrometry. Journal of Chromatography A 2004, 1050 (2), 173-178.